Eternus Review: I Worked In the Organization and Here is the Truth

Follow the world of nootropics and cognitive enhancement long enough and you are bound to run into conversations about anti-aging and longevity.

It is becoming increasingly popular to use diet, lifestyle, and supplementation to add years to life and add life to the years.

The Neurohacker Collective has launched Eternus, which is a nootropic stack dedicated to “beat aging”.

Whether a nootropic like this can actually “beat aging” is a major question covered in this Eternus review.

I have a unique position because I have developed a relationship with the founders since 2016 and more recently with their research and development department.

Within this review of Eternus, I’ll break down the rising trend of anti-aging, how Eternus compares to other nootropics, and answer “does Eternus work?” for inquiring minds.

Eternus Caters to the Anti-Aging Movement

Anti-aging and longevity are desires humans have had for hundreds of years. It is only within the past few decades that real longevity could be possible.

We are not there yet, but Harvard and MIT professor George Church hopes to help us “live long enough to live forever.” [1]

As one of the foremost researchers in synthetic biology who helped sequence the first genome, he is uniquely informed about how close we are to beating aging…

…but how does that help us average people today?

Unfortunately, you and I do not have access to the latest and greatest (albeit untested) technologies.

We may not have the $8,000 required to exchange young blood (a process known as parabiosis) [2], but that will not stop us from trying.

As my friend and colleague Dr. Mike T Nelson said recently, anti-aging and longevity is going to be the next big trend and if you read until the end of this post you will see why Eternus is going to dominate this category.

anti aging

Eternus Benefits with a Warning

According to the Neurohacker Collective (NHC) advertising material, there are a couple of major benefits of Eternus:

  • Support cell energy
  • Beat stress
  • Beat aging

eternus review

Enhancing cell energy is one of the best methods to upgrade performance.

This is why I formulated Elevate and why a team as forward looking as the NHC would focus on supporting the cells as well.

Each cell, whether it is a brain cell in the hippocampus supporting memory or a muscle cell in your arms supporting strength, requires energy.

The currency of energy is adenosine triphosphate (ATP).

The truth is, more energy in the cells is the #1 way to improve performance because it is sustainable and it is universal.

By universal I mean that every function, whether physical or mental, gets upgraded in contrast to stimulants and other nootropics.

Eternus does a fantastic job of increasing cell energy from a theoretical perspective (since they don’t yet have any studies showing this to be true).

Whether or not this will help anyone “beat aging” or “beat stress” is hard to say.

If they mean that Eternus will help someone beat aging and live forever, it’s probably not true. If instead they mean Eternus can support healthier aging (avoiding debilitating diseases later in life) then there is a possibility of that.

But here is the warning everyone should heed:

When it comes to improving cell energy and longevity, do not expect to feel anything.

Enhancing the energy in your cells is subtle. On a practical level, it does not often create any unique sensation. It isn’t going to feel like you have more energy necessarily.

This is one reason why understanding the individual ingredients is so valuable in deciding whether you want to buy Eternus.

Eternus Ingredient Review

Firstly, I’ll address the elephant in the room:

There are many ingredients in Eternus, which can seem overwhelming and potentially risky.

For some people (sometimes even myself) this is a turn off. This is where my intimate understanding of the NHC process (and team) comes in handy, however.

With a certain level of trust in the team and their process in developing Eternus, I have more confidence in recommending the product.

I will first break down some of the key ingredients with a list of the others below.

Tri-creatine malate

Creatine is the nootropic I have taken for the longest time consistently (6 years straight). Supplementing with creatine helps to produce more ATP in the cells [3].

This helps bodybuilders develop more strength and muscle mass, but also helps increase energy in the brain.

Some people are concerned with creatine producing bloat or water weight gain. The 1 gram of tri-creatine malate will probably not have that noticeable of an effect.

More importantly, malate is advantageous within the Krebs cycle of energy production.

Resveratrol (BioVin french red grapes extract 5% resveratrol)

Resveratrol is beneficial for humans because it is hormetic (provides stress to the body and then the body adapts).

According to Gregory Kelly (a naturopathic doctor and formulator at NHC), their goal with resveratrol was to take the lowest possible dosage that actually has some benefit.

They settled on 10 mg, which is a far cry from the 500 mg that Dr. David Sinclair popularized when he went on the Joe Rogan Experience.

Typically, this would scream “fairy dusting” (a concept where brands sprinkle small doses to claim a benefit when there is not enough to do so).

With Dr Kelly’s explanation, it makes sense. Adding too much stress (a high dose of resveratrol) daily may have real downsides.

Dr Sinclair is not wrong, but he might be more willing to take risks than other people in this space. The data is clear that some resveratrol is healthful for aging, though.

L-Tryptophan and Niacin

The ingredients nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are sexy right now. They’re popular and they are thought to increase NAD+ (which is purported to help with aging).

The problem is, these expensive supplements may not be any better than L-tryptophan and niacin.

The science is clear that NR / NMN are broken down orally into niacinamide. This is where L-tryptophan and niacin can become handy.

The L-tryptophan is the starting molecule for the de novo synthesis pathway (creating more NAD+) [4]. The niacin (nicotinic acid) helps produce NAD+ through the Preiss-Handler pathway [5].

These are more affordable supplements used to increase NAD+.

Polyphenols

Like resveratrol explained above, polyphenols are great tools from plants, which can support our own longevity.

Polyphenols are linked to increased longevity specifically because they activate longevity pathways in humans through a process known as “xenohormesis” [6].

There are many sources of polyphenols in our diet. They come in the form of coffee, but also grapes, blueberries, and tea. The polyphenols often provide the vibrant colors.

Specific polyphenols (many of which are in Eternus) can help to increase mitochondrial DNA [7], can restore mitochondrial abnormalities [8], and stimulate mitochondrial biogenesis (development of new mitochondria) [9].

Here is a comment made by Dr David Sinclair about xenohormesis (as he was involved in developing the concept):

Screen Shot 2019 04 01 at 10.39.39 AM

PQQ and CoQ10

Pyrrologuinoline quinone (PQQ) is a molecule that supports mitochondrial health. It may increase cellular NAD+ levels [10] and activates cytochrome c oxidase (CCO) [11], which enhances mitochondrial health.

PQQ is one of the darlings for improving the health of our mitochondria. Given this is key for cellular health and energy, it fits well with Eternus.

CoQ10 is another vital enzyme for mitochondrial health often spoken about in the same conversation with PQQ with some evidence that they work synergistically together.

Other Ingredients in Eternus

Beyond the ingredients above, there are dozens more in Eternus listed in the image below (36 in total).

eternus

If it seems alarming, know that many are simple vitamins, others are small doses of various polyphenols, and all of them have plenty of research…

…but how do you trust a product with so many darn ingredients?

It’s challenging to not feel a bit concerned with so many ingredients. I understand. Here is one of the main reasons I trust the formulation:

I saw the research NHC did to develop the product. In a spreadsheet with 414 rows and probably over 1,000 citations, I witnessed the competence of the team and their process.

As you will see from their white papers, ingredient explanations and other content, they have put a lot of thought into the product… and I’ve had the pleasure of seeing that from the inside.

There is a right and wrong way to do everything. A nootropic with too many ingredients sprinkled in without considering the pathways is risky and dangerous.

A nootropic with many ingredients that uses a complex-systems approach and leaves no stone left unturned is more valuable.

Are Antioxidants Really Beneficial?

Recently a big question has come up for me. Do antioxidants really help as much as the media and companies would like you to believe?

This Eternus review would not be complete without addressing that a balance of antioxidants is better than simply “more”. There is also a special way to use antioxidants.

Dr. Michael Ristow is a pioneer in this field who studies how (and why) antioxidants can be UNhealthy [12]

He clarifies that antioxidants like vitamin C or A can be unhelpful, but specific antioxidants that bolster mitochondrial defenses against reactive oxygen species (ROS) are helpful.

For example, researcher Navdeep Chandel questions the validity of CoQ10 as an antioxidant [13], but CoQ10 is a REDOX molecule that bolsters defenses.

Speaking with Dr Kelly who helped formulate Eternus, it is clear they understood this subtle difference and even removed ingredients that didn’t fit within Dr. Ristow’s criteria.

What Does Eternus Cost?

As with the original Neurohacker Collective product (Qualia), Eternus does not come cheap. The stand alone price is $159, which equates to approximately $5.30 per serving.

This is a far cry from the $1 – 2 per serving of most other products, but obviously Eternus is not like other products… and I’m going to help you get it cheaper.

A major education point I’ve made over the past 6 years is cycling various nootropics. This is less imperative when it comes to cell energy or mitochondrial support, but it is valuable as a general rule.

One way to make Eternus more affordable and still receive many of the longevity benefits is to take the Eternus nootropic in cycles or phases.

A phase cycling Eternus might look something like this:

  • Month 1 – 3: Consume Eternus (alongside other stimulants etc)
  • Month 4 – 6: Cycle off Eternus
  • Month 6 – 9: Consume Eternus
  • Month 9 – 12: Cycle off Eternus

It may be that this protocol provides a fraction of the value compared to consuming Eternus year round. I’d guess it’s still quite a valuable long-term boost.

If you managed a protocol like the one I’ve outlined AND you take advantage of the subscription pricing that NHC offers, the cost of Eternus looks much different.

At 50% off the first shipment, you are paying $79.50 for Month 1 and $139 for Month 2 and 3. This comes out to approximately $3.97 per serving.

Only $1.99 per serving over a 6 month period (assuming the cycling protocol I mentioned).

This makes it a lot more manageable. If you want to buy Eternus and save an additional 15%, use the code DENTON, which they have graciously provided.

Do it Yourself Eternus

When I first reviewed Qualia, I created a do it yourself analysis to see what it would cost…

For Eternus this was nearly impossible to do.

No human in their right mind would try to make Eternus themselves mostly because of how small many of the doses are.

In the first 11 ingredients, only 1 had a serving size where a comparable product was available (on Amazon). Many of the other doses were miniscule.

For example, getting a bag of thiamine HCl and dosing 1.4 mg would be the equivalent of 71,428 servings from a single bag. Eternus for eternity!

Ordinarily, I would find this cause for alarm. Many products practice “fairy dusting”, but this is not true for Eternus.

Firstly, all the ingredients show a % of their Daily Value (DV) and the median is 100%. They’re not skimping according to the recommended daily value.

Secondly, I saw the entire process of research and development. I acknowledged above, 414 rows of scientific evidence and thousands of citations led the NHC team to these doses.

I first thought I’d calculate how much it cost for you to make Eternus, but half-way through I realized it was not realistic to do so.

I’m glad that I did, though; I stumbled on yet another reason to buy Eternus (hint: you won’t get it any cheaper).

Eternus and Other Longevity Nootropics

The Eternus nootropic is not the only longevity-focused product on the market. Like-minded people think alike. Our Elevate product focuses on something similar.

There are other products formulated for longevity as well. No Eternus review would be complete without a comparison with the competition.

Nicotinamide Riboside and Nicotinamide Mononucleotide

Right now there is a lot of hype around nicotinamide riboside and mononucleotide, but they may not be any better than more basic (and cost effective) niacin equivalents.

This is one of the main reasons there is none within Eternus. Instead, the Neurohacker team included niacinamide and nicotinic acid, which they believe work equally well via different pathways.

I tend to believe the NHC R&D team on this one and relegate NR and NMN to valuable, but unnecessarily expensive.

Eternus vs Total Mitochondria (Onnit)

One of the first nootropics companies on the scene was Onnit (with Alpha Brain), but they too have graduated to launching a mitochondrial-support product.

Their product seems to include great, well-researched ingredients. CoQ10 and PQQ have synergy and with plenty of studies. Resveratrol has research as well, though dose matters.

The Onnit product is approximately 50 mg of resveratrol while Eternus has 10 mg.

The latter dose might make more sense since it is a hormetic stressor (the value comes from stressing the system). Thus, a small stress is better for regular use than a big stress.

The product is well-formulated and theoretically valuable, but the cost may be a stumbling block.

For $51 (and $1.70 per serving), it is a bit expensive for 3 ingredients (compared to Eternus’ 36).

Extrapolating out (which is an imperfect science), Onnit’s product is $17 per ingredient vs $4.42 per ingredient for Eternus.

total mitochondria sup facts

Eternus vs Elysium Basis

Elysium Health is a company founded with much fanfare and an all-star cast of doctors, scientists, and celebrity health influencers.

Among their scientific advisory board, there are 8 nobel laureates including Daniel Kahneman. 19 other scientists and engineers are supporting.

With all these stars, the group has created Elysium Basis, a combination of nicotinamide riboside (NR) and pterostilbene.

elysium basis

Unlike Eternus (and most nootropic stacks), Elysium Basis has a trial published in Nature finding that nicotinamide riboside and pterostilbene could increase NAD+ levels by 40% (in a single dose) [14].

A double dose increase NAD+ levels by 90% after 4 weeks.

The study used doses of 250 – 500 mg of nicotinamide riboside. The Elysium Basis product provides an adequate dose, but at a cost…

The cost of Elysium Basis is $60 for a single month supply ($2 per serving). All things considered, it isn’t that expensive, but compared to Eternus it is relatively simple.

Simplicity is not a bad thing.

Some people want a product with as few ingredients as possible and scientific evidence. If that is your preference, Elysium Basis might be a better fit… but…

In my research of NAD+ I had particularly informative conversations with Dr. Greg Kelly (and Daniel Schmachtenberger):

…we don’t care about NAD+ in isolation; we care about it because of what it allows cells to do. In this case, I don’t really see boosting it doing anything healthy…

If you have trust in the Neurohacker Collective R&D team (as I do), then you’ll experience a bigger bang for your buck to skip the expensive nicotinamide and go straight with the niacin equivalents in Eternus.

Personal Experience with Eternus

I went into my experience trying Eternus with low expectations. Most supplements that support cellular energy are theoretical at best.

Few mitochondrial support nootropics actually create subjective experiences.

The thing that became most apparent with Eternus is presence.

The experience of stillness is pleasant in a world of incredible stimulation; it also happens to be highly effective for workflow.

Here is the thing…

I got this added presence from a HALF dose. As is usual for me with all new nootropics (especially those with so many ingredients), I tried a half dose first to avoid adverse reactions.

The full dose provides an amplified feeling of presence as I later experienced.

Set your expectations low on whether you will feel anything on Eternus. You may be pleasantly surprised.

It’s one thing to receive a large dose of dopamine from a nootropic, but it is something altogether different to painstakingly increase the cellular production of ATP (energy).

To fault the Neurohacker Collective or say “Eternus doesn’t work” because you lack a subjective feeling is misguided.

The only downside (which seems to be a trend with NHC products!) is swallowing 8 large capsules every day in addition to whatever other supplements you’re taking.

Maybe it’s just me, but I struggle every time with large capsules and especially when there are many of them.

Eternus Side Effects

The only Eternus side effects that I experienced were gastrointestinal and it is hard to pinpoint whether that was caused by the nootropic or something else.

I am always modulating, tweaking, and testing my diet. There is no real evidence that Eternus was the cause of my gastrointestinal distress.

A few of the ingredients could create gastrointestinal distress, however. The sheer quantity of ingredients is one thing. Something like creatine (even in a 1 gram dose) might be another source of GI distress.

As one would expect, there isn’t a jittery experience or side effect so common with most nootropics.

Whether there are long-term side effects of Eternus is yet to be seen, but my belief is that there will be a few outliers with problems and nothing else.

Finally, there could be contraindications given there are so many ingredients in Eternus. If you are taking prescription medications or plan to utilize psychedelics, you might forego Eternus.

Why the Neurohacker Collective Creates Compelling Products

If you can’t already tell, I have insider relationships and partnerships with the Neurohacker Collective.

Some people might consider this a bias and it could be construed as such. If it does not feel good for you to buy Eternus because of that reason, I totally understand.

However, by being close to the organization, I’ve been able to learn from and see the process that their team uses to create products… and it’s better than most.

I’ve seen many companies in the nootropics space during my tenure as the founder and manager of Nootropedia.

The Neurohacker Collective has some serious advantages as a company. For one thing, they have money.

Over the past few years the Neurohacker Collective has raised over $5 million in various crowdfunding and private equity rounds [15] This is on top of the $13 million in total sales since 2016.

That kind of money gives the company a huge cushion to do research and development (R&D) the RIGHT way with lots of care and attention to detail.

In addition to the funding, the Neurohacker Collective has a stellar team Huffington Post called “revolutionary” [16]. That certainly shines through in their products.

If you found this valuable and have a desire to buy Eternus, go ahead and click this link and use the code DENTON to save 15%.

References

  1. https://arep.med.harvard.edu/gmc/
  2. https://www.businessinsider.com/young-blood-transfusions-launching-first-clinic-new-york-2018-9
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898252/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476425/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852209/
  6.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930135/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940809/
  8. https://www.ncbi.nlm.nih.gov/pubmed/29674247
  9. https://www.ncbi.nlm.nih.gov/pubmed/23755172
  10. https://www.ncbi.nlm.nih.gov/pubmed/29185343
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907713/
  12. https://blog.humanos.me/why-antioxidants-supplements-are-unhealthy-plus-compounds-that-mimic-exercise-guest-professor-michael-ristow/
  13. https://peterattiamd.com/navchandel/
  14. https://www.nature.com/articles/s41514-017-0016-9
  15. https://wefunder.com/neurohacker
  16. https://www.huffpost.com/entry/is-qualia-revolutionary-or-just-another-nootropic_b_597f4a21e4b0c69ef70529ce